SMA20/PMIS2 Is a Rapidly Evolving Sperm Membrane Alloantigen with Possible Species-Divergent Function in Fertilization

SMA20/PMIS2 Is a Rapidly Evolving Sperm Membrane Alloantigen with Possible Species-Divergent Function in Fertilization

Immunodominant alloantigens in pig sperm membranes include 15 known gene products and a previously undiscovered <i>M</i>r 20,000 sperm membrane-specific protein (SMA20). Here we characterize SMA20 and identify it as the unannotated pig ortholog of PMIS2. A composite SMA20 cDNA encoded a...

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Bibliographic Details
Main Authors: Nathaly Cormier, Asha E. Worsham, Kinsey A. Rich, Daniel M. Hardy
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:International Journal of Molecular Sciences
Subjects:
fertilization
spermatozoa
cell membrane
molecular evolution
alloimmunity
genome annotation
Online Access:https://www.mdpi.com/1422-0067/25/7/3652

Internet

https://www.mdpi.com/1422-0067/25/7/3652

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