Evaluation of OspA vaccination-induced serological correlates of protection against Lyme borreliosis in a mouse model.

Evaluation of OspA vaccination-induced serological correlates of protection against Lyme borreliosis in a mouse model.

For clinical development of a novel multivalent OspA vaccine against Lyme borreliosis, serological assays are required which can be used to establish immune correlates of protection against infection with Borrelia.Four assays (an OspA IgG ELISA, a competitive inhibition (CI) ELISA, a Borrelia surfac...

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Bibliographic Details
Main Authors: Michael G Schwendinger, Maria O'Rourke, Andreas Traweger, Helga Savidis-Dacho, Andreas Pilz, Daniel Portsmouth, Ian Livey, P Noel Barrett, Brian A Crowe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3832494?pdf=render

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http://europepmc.org/articles/PMC3832494?pdf=render

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