Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways

Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways

In a rotenone-induced Parkinson’s disease (PD) rat model, behavioral investigation, pathological examination, inflammatory factor analysis, and mitochondrial structure and function investigation verified the anti-PD efficacy of nardosinone. A combined transcriptome and proteome analysis proposed tha...

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Bibliographic Details
Main Authors: Li-hua Bian, Zi-wei Yao, Zhe-yi Wang, Xiao-mei Wang, Qiu-yu Li, Xue Yang, Jia-yuan Li, Xiao-jia Wei, Guo-hui Wan, Yu-qing Wang, Jin-li Shi, Jian-you Guo
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Parkinson’s disease
Nardosinone
slc38a2
GABAergic synaptic pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222006588

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http://www.sciencedirect.com/science/article/pii/S0753332222006588

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