Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways
In a rotenone-induced Parkinson’s disease (PD) rat model, behavioral investigation, pathological examination, inflammatory factor analysis, and mitochondrial structure and function investigation verified the anti-PD efficacy of nardosinone. A combined transcriptome and proteome analysis proposed tha...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-09-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222006588 |
| _version_ | 1811188121651380224 |
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| author | Li-hua Bian Zi-wei Yao Zhe-yi Wang Xiao-mei Wang Qiu-yu Li Xue Yang Jia-yuan Li Xiao-jia Wei Guo-hui Wan Yu-qing Wang Jin-li Shi Jian-you Guo |
| author_facet | Li-hua Bian Zi-wei Yao Zhe-yi Wang Xiao-mei Wang Qiu-yu Li Xue Yang Jia-yuan Li Xiao-jia Wei Guo-hui Wan Yu-qing Wang Jin-li Shi Jian-you Guo |
| author_sort | Li-hua Bian |
| collection | DOAJ |
| description | In a rotenone-induced Parkinson’s disease (PD) rat model, behavioral investigation, pathological examination, inflammatory factor analysis, and mitochondrial structure and function investigation verified the anti-PD efficacy of nardosinone. A combined transcriptome and proteome analysis proposed that the anti-PD target of nardosinone is the slc38a2 gene and may involve the GABAergic synaptic pathway and cAMP-signaling pathway. Analysis of targeted slc38a2 knockout cells and expression of key enzyme-encoding genes in both pathways verified the target and pathways proposed by the ‘omics analysis. This further confirms that nardosinone can regulate the slc38a2 gene, a potential new target for the treatment of Parkinson's disease, and plays an anti-PD role through the GABAergic synaptic and cAMP pathways. |
| first_indexed | 2024-04-11T14:14:09Z |
| format | Article |
| id | doaj.art-f17a84d70e3744bfa236a471ece1417d |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T14:14:09Z |
| publishDate | 2022-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-f17a84d70e3744bfa236a471ece1417d2022-12-22T04:19:36ZengElsevierBiomedicine & Pharmacotherapy0753-33222022-09-01153113269Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathwaysLi-hua Bian0Zi-wei Yao1Zhe-yi Wang2Xiao-mei Wang3Qiu-yu Li4Xue Yang5Jia-yuan Li6Xiao-jia Wei7Guo-hui Wan8Yu-qing Wang9Jin-li Shi10Jian-you Guo11School of Chinese Materia Medica, Beijing University of Chinese Medicine, 11A North Third Ring East Road, Chaoyang District, Beijing 100029, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11A North Third Ring East Road, Chaoyang District, Beijing 100029, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11A North Third Ring East Road, Chaoyang District, Beijing 100029, China; Qilu Hospital, Shandong University, Jinan 250012, Shandong, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11A North Third Ring East Road, Chaoyang District, Beijing 100029, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11A North Third Ring East Road, Chaoyang District, Beijing 100029, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11A North Third Ring East Road, Chaoyang District, Beijing 100029, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11A North Third Ring East Road, Chaoyang District, Beijing 100029, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11A North Third Ring East Road, Chaoyang District, Beijing 100029, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11A North Third Ring East Road, Chaoyang District, Beijing 100029, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11A North Third Ring East Road, Chaoyang District, Beijing 100029, ChinaSchool of Chinese Materia Medica, Beijing University of Chinese Medicine, 11A North Third Ring East Road, Chaoyang District, Beijing 100029, China; Corresponding authors.CAS Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, 4A DatunRoad, Chaoyang District, Beijing 100101, China; Corresponding authors.In a rotenone-induced Parkinson’s disease (PD) rat model, behavioral investigation, pathological examination, inflammatory factor analysis, and mitochondrial structure and function investigation verified the anti-PD efficacy of nardosinone. A combined transcriptome and proteome analysis proposed that the anti-PD target of nardosinone is the slc38a2 gene and may involve the GABAergic synaptic pathway and cAMP-signaling pathway. Analysis of targeted slc38a2 knockout cells and expression of key enzyme-encoding genes in both pathways verified the target and pathways proposed by the ‘omics analysis. This further confirms that nardosinone can regulate the slc38a2 gene, a potential new target for the treatment of Parkinson's disease, and plays an anti-PD role through the GABAergic synaptic and cAMP pathways.http://www.sciencedirect.com/science/article/pii/S0753332222006588Parkinson’s diseaseNardosinoneslc38a2GABAergic synaptic pathway |
| spellingShingle | Li-hua Bian Zi-wei Yao Zhe-yi Wang Xiao-mei Wang Qiu-yu Li Xue Yang Jia-yuan Li Xiao-jia Wei Guo-hui Wan Yu-qing Wang Jin-li Shi Jian-you Guo Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways Biomedicine & Pharmacotherapy Parkinson’s disease Nardosinone slc38a2 GABAergic synaptic pathway |
| title | Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways |
| title_full | Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways |
| title_fullStr | Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways |
| title_full_unstemmed | Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways |
| title_short | Nardosinone regulates the slc38a2 gene to alleviate Parkinson's symptoms in rats through the GABAergic synaptic and cAMP pathways |
| title_sort | nardosinone regulates the slc38a2 gene to alleviate parkinson s symptoms in rats through the gabaergic synaptic and camp pathways |
| topic | Parkinson’s disease Nardosinone slc38a2 GABAergic synaptic pathway |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222006588 |
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