Therapeutic effects of eperisone on pulmonary fibrosis via preferential suppression of fibroblast activity

Abstract Although the exact pathogenesis of idiopathic pulmonary fibrosis (IPF) is still unknown, the transdifferentiation of fibroblasts into myofibroblasts and the production of extracellular matrix components such as collagen, triggered by alveolar epithelial cell injury, are important mechanisms...

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Bibliographic Details
Main Authors: Ken-ichiro Tanaka, Mikako Shimoda, Toshifumi Sugizaki, Maki Ikeda, Ayaka Takafuji, Masahiro Kawahara, Naoki Yamakawa, Tohru Mizushima
Format: Article
Language:English
Published: Nature Publishing Group 2022-02-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-022-00851-7