Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis

The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-...

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Bibliographic Details
Main Authors: Lang Rao, Lei Wu, Zhida Liu, Rui Tian, Guocan Yu, Zijian Zhou, Kuikun Yang, Hong-Gang Xiong, Anli Zhang, Guang-Tao Yu, Wenjing Sun, Han Xu, Jingya Guo, Andrew Li, Hongmin Chen, Zhi-Jun Sun, Yang-Xin Fu, Xiaoyuan Chen
Format: Article
Language:English
Published: Nature Portfolio 2020-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-18626-y

Internet

https://doi.org/10.1038/s41467-020-18626-y

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