Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis
The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-...
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-09-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-18626-y |
| _version_ | 1828973528002592768 |
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| author | Lang Rao Lei Wu Zhida Liu Rui Tian Guocan Yu Zijian Zhou Kuikun Yang Hong-Gang Xiong Anli Zhang Guang-Tao Yu Wenjing Sun Han Xu Jingya Guo Andrew Li Hongmin Chen Zhi-Jun Sun Yang-Xin Fu Xiaoyuan Chen |
| author_facet | Lang Rao Lei Wu Zhida Liu Rui Tian Guocan Yu Zijian Zhou Kuikun Yang Hong-Gang Xiong Anli Zhang Guang-Tao Yu Wenjing Sun Han Xu Jingya Guo Andrew Li Hongmin Chen Zhi-Jun Sun Yang-Xin Fu Xiaoyuan Chen |
| author_sort | Lang Rao |
| collection | DOAJ |
| description | The application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-tumor immune responses. |
| first_indexed | 2024-12-14T13:47:32Z |
| format | Article |
| id | doaj.art-f17de9f800584c86b4d4c951356870bb |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T13:47:32Z |
| publishDate | 2020-09-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f17de9f800584c86b4d4c951356870bb2022-12-21T22:59:16ZengNature PortfolioNature Communications2041-17232020-09-0111111310.1038/s41467-020-18626-yHybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasisLang Rao0Lei Wu1Zhida Liu2Rui Tian3Guocan Yu4Zijian Zhou5Kuikun Yang6Hong-Gang Xiong7Anli Zhang8Guang-Tao Yu9Wenjing Sun10Han Xu11Jingya Guo12Andrew Li13Hongmin Chen14Zhi-Jun Sun15Yang-Xin Fu16Xiaoyuan Chen17Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthState Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan UniversityDepartment of Pathology, University of Texas Southwestern Medical CenterLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthState Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan UniversityDepartment of Pathology, University of Texas Southwestern Medical CenterState Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan UniversityCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversityCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversityChinese Academy of Sciences Key Laboratory of Infection and Immunity, Institute of Biophysics, Chinese Academy of SciencesDepartment of Biomedical Engineering, Johns Hopkins UniversityCenter for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen UniversityState Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST), Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan UniversityDepartment of Pathology, University of Texas Southwestern Medical CenterLaboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of HealthThe application of STING agonists and the blockade of the SIRPα–CD47 signaling axis are emerging immunotherapeutic strategies. Here the authors show that hybrid cellular membrane nanovesicles loaded with a STING agonist or overexpressing high-affinity SIRPα variants can be exploited to promote anti-tumor immune responses.https://doi.org/10.1038/s41467-020-18626-y |
| spellingShingle | Lang Rao Lei Wu Zhida Liu Rui Tian Guocan Yu Zijian Zhou Kuikun Yang Hong-Gang Xiong Anli Zhang Guang-Tao Yu Wenjing Sun Han Xu Jingya Guo Andrew Li Hongmin Chen Zhi-Jun Sun Yang-Xin Fu Xiaoyuan Chen Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis Nature Communications |
| title | Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis |
| title_full | Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis |
| title_fullStr | Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis |
| title_full_unstemmed | Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis |
| title_short | Hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis |
| title_sort | hybrid cellular membrane nanovesicles amplify macrophage immune responses against cancer recurrence and metastasis |
| url | https://doi.org/10.1038/s41467-020-18626-y |
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