SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells

SYK ubiquitination by CBL E3 ligases restrains cross-presentation of dead cell-associated antigens by type 1 dendritic cells

Summary: Cross-presentation of dead cell-associated antigens by conventional dendritic cells type 1 (cDC1s) is critical for CD8+ T cells response against many tumors and viral infections. It is facilitated by DNGR-1 (CLEC9A), an SYK-coupled cDC1 receptor that detects dead cell debris. Here, we repor...

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Bibliographic Details
Main Authors: Conor M. Henry, Carlos A. Castellanos, Michael D. Buck, Evangelos Giampazolias, Bruno Frederico, Ana Cardoso, Neil C. Rogers, Oliver Schulz, Sonia Lee, Johnathan Canton, Peter Faull, Ambrosius P. Snijders, Bhopal Mohapatra, Hamid Band, Caetano Reis e Sousa
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723015188

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http://www.sciencedirect.com/science/article/pii/S2211124723015188

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