Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23

Osteocyte Egln1/Phd2 links oxygen sensing and biomineralization via FGF23

Abstract Osteocytes act within a hypoxic environment to control key steps in bone formation. FGF23, a critical phosphate-regulating hormone, is stimulated by low oxygen/iron in acute and chronic diseases, however the molecular mechanisms directing this process remain unclear. Our goal was to identif...

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Bibliographic Details
Main Authors: Megan L. Noonan, Pu Ni, Emmanuel Solis, Yamil G. Marambio, Rafiou Agoro, Xiaona Chu, Yue Wang, Hongyu Gao, Xiaoling Xuei, Erica L. Clinkenbeard, Guanglong Jiang, Sheng Liu, Steve Stegen, Geert Carmeliet, William R. Thompson, Yunlong Liu, Jun Wan, Kenneth E. White
Format: Article
Language:English
Published: Nature Publishing Group 2023-01-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-022-00241-w

Internet

https://doi.org/10.1038/s41413-022-00241-w

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