Hedgehog-regulated ubiquitination controls smoothened trafficking and cell surface expression in Drosophila.
Hedgehog transduces signal by promoting cell surface expression of the seven-transmembrane protein Smoothened (Smo) in Drosophila, but the underlying mechanism remains unknown. Here we demonstrate that Smo is downregulated by ubiquitin-mediated endocytosis and degradation, and that Hh increases Smo...
| Prif Awduron: | , , , , , |
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| Fformat: | Erthygl |
| Iaith: | English |
| Cyhoeddwyd: |
Public Library of Science (PLoS)
2012-01-01
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| Cyfres: | PLoS Biology |
| Mynediad Ar-lein: | https://journals.plos.org/plosbiology/article/file?id=10.1371/journal.pbio.1001239&type=printable |