Inhibitory Effect of Imperatorin on the Pharmacokinetics of Diazepam In Vitro and In Vivo

Inhibitory Effect of Imperatorin on the Pharmacokinetics of Diazepam In Vitro and In Vivo

BackgroundDiazepam is a benzodiazepine drug used to treat anxiety, insomnia, and muscle spasms. Imperatorin is a phytochemical isolated from medicinal plants and is widely used in herbal medicine. The aim of this study was to investigate the interactions between imperatorin and diazepam in vitro and...

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Bibliographic Details
Main Authors: Yunfang Zhou, Deru Meng, Feifei Chen, Zhengping Wu, Binglan Wang, Shuanghu Wang, Peiwu Geng, Dapeng Dai, Quan Zhou, Weiwen Qiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-09-01
Series:Frontiers in Pharmacology
Subjects:
imperatorin
diazepam
drug-drug interaction
pharmacokinetics
P450
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01079/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01079/full

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