Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice
Abstract Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockou...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2021-11-01
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| Series: | Molecular Brain |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13041-021-00879-3 |
| _version_ | 1830301406102290432 |
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| author | Mitsuaki Kashiwagi Mika Kanuka Kaeko Tanaka Masayo Fujita Ayaka Nakai Chika Tatsuzawa Kazuto Kobayashi Kazutaka Ikeda Yu Hayashi |
| author_facet | Mitsuaki Kashiwagi Mika Kanuka Kaeko Tanaka Masayo Fujita Ayaka Nakai Chika Tatsuzawa Kazuto Kobayashi Kazutaka Ikeda Yu Hayashi |
| author_sort | Mitsuaki Kashiwagi |
| collection | DOAJ |
| description | Abstract Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockout of tyrosine hydroxylase and its specific rescue in noradrenergic and adrenergic neurons. We found that DD mice have reduced time spent in wakefulness. Unexpectedly, DD mice also exhibited a marked reduction in the time spent in rapid eye movement (REM) sleep. The electroencephalogram power spectrum of all vigilance states in DD mice were also affected. These results support the current understanding of the critical roles of the dopaminergic system in maintaining wakefulness and also implicate its previously unknown effects on REM sleep. |
| first_indexed | 2024-12-19T08:48:48Z |
| format | Article |
| id | doaj.art-f185785df9594fc2a899c8013e7919f3 |
| institution | Directory Open Access Journal |
| issn | 1756-6606 |
| language | English |
| last_indexed | 2024-12-19T08:48:48Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | Molecular Brain |
| spelling | doaj.art-f185785df9594fc2a899c8013e7919f32022-12-21T20:28:47ZengBMCMolecular Brain1756-66062021-11-011411410.1186/s13041-021-00879-3Impaired wakefulness and rapid eye movement sleep in dopamine-deficient miceMitsuaki Kashiwagi0Mika Kanuka1Kaeko Tanaka2Masayo Fujita3Ayaka Nakai4Chika Tatsuzawa5Kazuto Kobayashi6Kazutaka Ikeda7Yu Hayashi8International Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaAddictive Substance Project, Tokyo Metropolitan Institute of Medical ScienceInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaDepartment of Molecular Genetics, Institute of Biomedical Sciences, Fukushima Medical UniversityAddictive Substance Project, Tokyo Metropolitan Institute of Medical ScienceInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of TsukubaAbstract Despite the established roles of the dopaminergic system in promoting arousal, the effects of loss of dopamine on the patterns of sleep and wakefulness remain elusive. Here, we examined the sleep architecture of dopamine-deficient (DD) mice, which were previously developed by global knockout of tyrosine hydroxylase and its specific rescue in noradrenergic and adrenergic neurons. We found that DD mice have reduced time spent in wakefulness. Unexpectedly, DD mice also exhibited a marked reduction in the time spent in rapid eye movement (REM) sleep. The electroencephalogram power spectrum of all vigilance states in DD mice were also affected. These results support the current understanding of the critical roles of the dopaminergic system in maintaining wakefulness and also implicate its previously unknown effects on REM sleep.https://doi.org/10.1186/s13041-021-00879-3DopamineMouseNREM sleepREM sleep |
| spellingShingle | Mitsuaki Kashiwagi Mika Kanuka Kaeko Tanaka Masayo Fujita Ayaka Nakai Chika Tatsuzawa Kazuto Kobayashi Kazutaka Ikeda Yu Hayashi Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice Molecular Brain Dopamine Mouse NREM sleep REM sleep |
| title | Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice |
| title_full | Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice |
| title_fullStr | Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice |
| title_full_unstemmed | Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice |
| title_short | Impaired wakefulness and rapid eye movement sleep in dopamine-deficient mice |
| title_sort | impaired wakefulness and rapid eye movement sleep in dopamine deficient mice |
| topic | Dopamine Mouse NREM sleep REM sleep |
| url | https://doi.org/10.1186/s13041-021-00879-3 |
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