BRCA2 C-Terminal RAD51-Binding Domain Confers Resistance to DNA-Damaging Agents

BRCA2 C-Terminal RAD51-Binding Domain Confers Resistance to DNA-Damaging Agents

Breast cancer type 2 susceptibility (BRCA2) protein is crucial for initiating DNA damage repair after chemotherapy with DNA interstrand crosslinking agents or X-ray irradiation, which induces DNA double-strand breaks. BRCA2 contains a C-terminal RAD51-binding domain (CTRBD) that interacts with RAD51...

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Bibliographic Details
Main Authors: Zida Zhu, Taisuke Kitano, Masami Morimatsu, Arisa Tanaka, Ryo Morioka, Xianghui Lin, Koichi Orino, Yasunaga Yoshikawa
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
BRCA2
DNA damage repair
homologous recombination repair
C-terminal RAD51-binding domain
X-ray irradiation
mitomycin C
Online Access:https://www.mdpi.com/1422-0067/23/7/4060

Internet

https://www.mdpi.com/1422-0067/23/7/4060

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