KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection

Determination of the mutations' status in the KRAS and NRAS genes is a necessary requirement in the treatment of patients with colorectal cancer (CRC). Patients with certain mutations in the KRAS and NRAS genes are resistant to anti-EGFR drug therapy and have a lower median survival rate than t...

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Bibliographic Details
Main Authors: Olga I. Brovkina, Alexey G. Nikitin
Format: Article
Language:English
Published: Eco-vector 2021-03-01
Series:Клиническая практика
Subjects:
Online Access:https://journals.eco-vector.com/clinpractice/article/viewFile/63875/pdf