KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection
Determination of the mutations' status in the KRAS and NRAS genes is a necessary requirement in the treatment of patients with colorectal cancer (CRC). Patients with certain mutations in the KRAS and NRAS genes are resistant to anti-EGFR drug therapy and have a lower median survival rate than t...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Eco-vector
2021-03-01
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| Series: | Клиническая практика |
| Subjects: | |
| Online Access: | https://journals.eco-vector.com/clinpractice/article/viewFile/63875/pdf |
| _version_ | 1797716492354060288 |
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| author | Olga I. Brovkina Alexey G. Nikitin |
| author_facet | Olga I. Brovkina Alexey G. Nikitin |
| author_sort | Olga I. Brovkina |
| collection | DOAJ |
| description | Determination of the mutations' status in the KRAS and NRAS genes is a necessary requirement in the treatment of patients with colorectal cancer (CRC). Patients with certain mutations in the KRAS and NRAS genes are resistant to anti-EGFR drug therapy and have a lower median survival rate than those with WT (wild type) genotypes, that indicates a negative prognosis in the case when mutations are present. Currently, there are no registered targeted drugs for carriers of the KRAS and NRAS genes mutations, however, preparations based on small molecules are under way. The gold standard for detecting mutations in the KRAS and NRAS genes is the analysis of the biopsy material in paraffin blocks. However, this method has significant limitations that can be circumvented by the analysis of circulating tumor DNA a promising new method in the diagnosis of colorectal cancer. |
| first_indexed | 2024-03-12T08:22:13Z |
| format | Article |
| id | doaj.art-f188be48a67348c79d1798ffd8d2b72d |
| institution | Directory Open Access Journal |
| issn | 2220-3095 2618-8627 |
| language | English |
| last_indexed | 2024-03-12T08:22:13Z |
| publishDate | 2021-03-01 |
| publisher | Eco-vector |
| record_format | Article |
| series | Клиническая практика |
| spelling | doaj.art-f188be48a67348c79d1798ffd8d2b72d2023-09-02T18:22:15ZengEco-vectorКлиническая практика2220-30952618-86272021-03-01121667110.17816/clinpract6387559337KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detectionOlga I. Brovkina0https://orcid.org/0000-0002-0946-7331Alexey G. Nikitin1https://orcid.org/0000-0001-9762-3383Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of RussiaFederal Research and Clinical Center of Specialized Medical Care and Medical Technologies FMBA of RussiaDetermination of the mutations' status in the KRAS and NRAS genes is a necessary requirement in the treatment of patients with colorectal cancer (CRC). Patients with certain mutations in the KRAS and NRAS genes are resistant to anti-EGFR drug therapy and have a lower median survival rate than those with WT (wild type) genotypes, that indicates a negative prognosis in the case when mutations are present. Currently, there are no registered targeted drugs for carriers of the KRAS and NRAS genes mutations, however, preparations based on small molecules are under way. The gold standard for detecting mutations in the KRAS and NRAS genes is the analysis of the biopsy material in paraffin blocks. However, this method has significant limitations that can be circumvented by the analysis of circulating tumor DNA a promising new method in the diagnosis of colorectal cancer.https://journals.eco-vector.com/clinpractice/article/viewFile/63875/pdfcolorectal cancermutations in the kras, nras genesbiomarkerscirculating tumor dna |
| spellingShingle | Olga I. Brovkina Alexey G. Nikitin KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection Клиническая практика colorectal cancer mutations in the kras, nras genes biomarkers circulating tumor dna |
| title | KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection |
| title_full | KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection |
| title_fullStr | KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection |
| title_full_unstemmed | KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection |
| title_short | KRAS and NRAS genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection |
| title_sort | kras and nras genes mutations as biomarkers in the therapy of colorectal cancer and the basic methods of their detection |
| topic | colorectal cancer mutations in the kras, nras genes biomarkers circulating tumor dna |
| url | https://journals.eco-vector.com/clinpractice/article/viewFile/63875/pdf |
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