Decoding Conformational Imprint of Convoluted Molecular Interactions Between Prenylflavonoids and Aggregated Amyloid-Beta42 Peptide Causing Alzheimer’s Disease

Decoding Conformational Imprint of Convoluted Molecular Interactions Between Prenylflavonoids and Aggregated Amyloid-Beta42 Peptide Causing Alzheimer’s Disease

Protein misfolding occurs due to the loss of native protein structure and adopts an abnormal structure, wherein the misfolded proteins accumulate and form aggregates, which result in the formation of amyloid fibrils that are associated with neurodegenerative diseases. Amyloid beta (Aβ42) aggregation...

Full description

Bibliographic Details
Main Authors: E. Srinivasan, G. Chandrasekhar, P. Chandrasekar, K. Anbarasu, AS Vickram, Iftikhar Aslam Tayubi, R. Rajasekaran, Rohini Karunakaran
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Chemistry
Subjects:
alzheimer’s
amyloid-beta
neobavaisoflavone
herbal active compounds
computational screening
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.753146/full

Internet

https://www.frontiersin.org/articles/10.3389/fchem.2021.753146/full

Similar Items