Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide

Neutral sphingomyelinase activation in endothelial and glial cell death induced by amyloid beta-peptide

We have explored the molecular mechanism underlying amyloid beta-peptide (Aβ)-mediated cytotoxicity in vitro. Exposure of murine cerebral endothelial cells (CECs) or C6 glioma cells to Aβ25-35 resulted in dose-dependent cell death. Ceramide is a pro-apoptotic lipid mediator. Forced elevation of cell...

Full description

Bibliographic Details
Main Authors: Ding-I Yang, Chen-Hsiung Yeh, Shawei Chen, Jan Xu, Chung Y. Hsu
Format: Article
Language:English
Published: Elsevier 2004-10-01
Series:Neurobiology of Disease
Subjects:
Acidic sphingomyelinase
Alzheimer's disease
Cerebral amyloid angiopathy
Blood–brain barrier
Ceramide
Sphingomyelinase
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996104001305

Internet

http://www.sciencedirect.com/science/article/pii/S0969996104001305

Similar Items