TMBur: a distributable tumor mutation burden approach for whole genome sequencing

TMBur: a distributable tumor mutation burden approach for whole genome sequencing

Abstract Background Tumor mutation burden (TMB) is a key characteristic used in a tumor-type agnostic context to inform the use of immune checkpoint inhibitors (ICI). Accurate and consistent measurement of TMB is crucial as it can significantly impact patient selection for therapy and clinical trial...

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Main Authors: Emma Titmuss, Richard D. Corbett, Scott Davidson, Sanna Abbasi, Laura M. Williamson, Erin D. Pleasance, Adam Shlien, Daniel J. Renouf, Steven J. M. Jones, Janessa Laskin, Marco A. Marra
Format: Article
Language:English
Published: BMC 2022-09-01
Series:BMC Medical Genomics
Subjects:
Tumor mutation burden
Whole genome and transcriptome analysis (WGTA)
Immune checkpoint inhibitors
Online Access:https://doi.org/10.1186/s12920-022-01348-z

Internet

https://doi.org/10.1186/s12920-022-01348-z

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