Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function

Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function

Summary: Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of beta cell function. Here, we show that an lncRNA-transcribed antisense to Pax6, annotated as Pax6os1/PAX6-AS1, was upregulated by high glucose concentrations in human as well as murine beta cell lines and islets. Elevated...

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Bibliographic Details
Main Authors: Livia Lopez-Noriega, Rebecca Callingham, Aida Martinez-Sánchez, Sameena Nawaz, Grazia Pizza, Nejc Haberman, Nevena Cvetesic, Marie-Sophie Nguyen-Tu, Boris Lenhard, Piero Marchetti, Lorenzo Piemonti, Eelco de Koning, A.M. James Shapiro, Paul R. Johnson, Isabelle Leclerc, Benoit Hastoy, Benoit R. Gauthier, Timothy J. Pullen, Guy A. Rutter
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:iScience
Subjects:
Cell biology
Cellular physiology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224027457

Internet

http://www.sciencedirect.com/science/article/pii/S2589004224027457

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