AID Contributes to Accelerated Disease Progression in the TCL1 Mouse Transplant Model for CLL

AID Contributes to Accelerated Disease Progression in the TCL1 Mouse Transplant Model for CLL

Adaptive somatic mutations conferring treatment resistance and accelerated disease progression is still a major problem in cancer therapy. Additionally in CLL, patients receiving novel, efficient drugs frequently become treatment refractory and eventually relapse. Activation-induced deaminase (AID)...

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Bibliographic Details
Main Authors: Maria Schubert, Franz Josef Gassner, Michael Huemer, Jan Philip Höpner, Ekaterina Akimova, Markus Steiner, Alexander Egle, Richard Greil, Nadja Zaborsky, Roland Geisberger
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Cancers
Subjects:
activation induced deaminase (AID)
CLL
clonal evolution
deaminase
drug resistance
Online Access:https://www.mdpi.com/2072-6694/13/11/2619

Internet

https://www.mdpi.com/2072-6694/13/11/2619

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