NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice

NKB signaling in the posterodorsal medial amygdala stimulates gonadotropin release in a kisspeptin-independent manner in female mice

Neurokinin B (NKB) signaling is critical for reproduction in all studied species. The existing consensus is that NKB induces GnRH release via kisspeptin (Kiss1) stimulation in the arcuate nucleus. However, the stimulatory action of NKB is dependent on circulating estrogen (E2) levels, without which,...

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Bibliographic Details
Main Authors: Chrysanthi Fergani, Silvia Leon, Stephanie L Padilla, Anne MJ Verstegen, Richard D Palmiter, Victor M Navarro
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2018-12-01
Series:eLife
Subjects:
reproduction
amygdala
kisspeptin
neurokinin B
neuroendocrinology
estradiol
Online Access:https://elifesciences.org/articles/40476

Internet

https://elifesciences.org/articles/40476

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