Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration

Modulation of chromatin structure by the FACT histone chaperone complex regulates HIV-1 integration

Abstract Background Insertion of retroviral genome DNA occurs in the chromatin of the host cell. This step is modulated by chromatin structure as nucleosomes compaction was shown to prevent HIV-1 integration and chromatin remodeling has been reported to affect integration efficiency. LEDGF/p75-media...

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Bibliographic Details
Main Authors: Julien Matysiak, Paul Lesbats, Eric Mauro, Delphine Lapaillerie, Jean-William Dupuy, Angelica P. Lopez, Mohamed Salah Benleulmi, Christina Calmels, Marie-Line Andreola, Marc Ruff, Manuel Llano, Olivier Delelis, Marc Lavigne, Vincent Parissi
Format: Article
Language:English
Published: BMC 2017-07-01
Series:Retrovirology
Subjects:
Retroviral integration
HIV-1
Integrase
Chromatin
Nucleosome
FACT
Online Access:http://link.springer.com/article/10.1186/s12977-017-0363-4

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http://link.springer.com/article/10.1186/s12977-017-0363-4

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