CTLA-4 expressed by human dendritic cells modulates thei cytokine secretion and induction of T cell proliferation

CTLA-4 expressed by human dendritic cells modulates thei cytokine secretion and induction of T cell proliferation

<p>CTLA-4 is the major nefative regulator of T cell response. We have analyzed the expression of CTLA-4 in human monocytes and monocyte-derived DCs and the effects of its engagement on cytokine production and T cell stimulatory activity by mature DCs (mDCs). We found the CTLA-4 was highly expr...

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Bibliographic Details
Main Authors: S. Laurent, P. Carrega, D. Saverino, P. Piccioli, M. Camoriamo, A. Morabito, B. Dozin, V. Fontana, R. Simone, L. Mortara, M.C. Mingari, G. Ferlazzo, M.P. Pistillo
Format: Article
Language:English
Published: PAGEPress Publications 2011-01-01
Series:Journal of Biological Research
Subjects:
CTLA-4, DC, cytokine secretion, T cell proliferation
Online Access:http://www.pagepressjournals.org/index.php/jbr/article/view/4651

Internet

http://www.pagepressjournals.org/index.php/jbr/article/view/4651

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