CTLA-4 expressed by human dendritic cells modulates thei cytokine secretion and induction of T cell proliferation
<p>CTLA-4 is the major nefative regulator of T cell response. We have analyzed the expression of CTLA-4 in human monocytes and monocyte-derived DCs and the effects of its engagement on cytokine production and T cell stimulatory activity by mature DCs (mDCs). We found the CTLA-4 was highly expr...
Main Authors: | S. Laurent, P. Carrega, D. Saverino, P. Piccioli, M. Camoriamo, A. Morabito, B. Dozin, V. Fontana, R. Simone, L. Mortara, M.C. Mingari, G. Ferlazzo, M.P. Pistillo |
---|---|
Format: | Article |
Language: | English |
Published: |
PAGEPress Publications
2011-01-01
|
Series: | Journal of Biological Research |
Subjects: | |
Online Access: | http://www.pagepressjournals.org/index.php/jbr/article/view/4651 |
Similar Items
-
Addressing the Elephant in the Immunotherapy Room: Effector T-Cell Priming versus Depletion of Regulatory T-Cells by Anti-CTLA-4 Therapy
by: Megan M Y Hong, et al.
Published: (2022-03-01) -
CTLA4 DNA methylation is associated with CTLA-4 expression and predicts response to immunotherapy in head and neck squamous cell carcinoma
by: Friederike Hoffmann, et al.
Published: (2023-07-01) -
CTLA-4 silencing in dendritic cells loaded with colorectal cancer cell lysate improves autologous T cell responses in vitro
by: Farid Ghorbaninezhad, et al.
Published: (2022-08-01) -
Identification of CTLA-4-Positive Cells in the Human Tonsil
by: Markus Tiemann, et al.
Published: (2021-04-01) -
Alleviating psoriatic skin inflammation through augmentation of Treg cells via CTLA-4 signaling peptide
by: Woo-Sung Lee, et al.
Published: (2023-09-01)