A new insight into RecA filament regulation by RecX from the analysis of conformation-specific interactions

A new insight into RecA filament regulation by RecX from the analysis of conformation-specific interactions

RecA protein mediates homologous recombination repair in bacteria through assembly of long helical filaments on ssDNA in an ATP-dependent manner. RecX, an important negative regulator of RecA, is known to inhibit RecA activity by stimulating the disassembly of RecA nucleoprotein filaments. Here we u...

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Bibliographic Details
Main Authors: Aleksandr Alekseev, Georgii Pobegalov, Natalia Morozova, Alexey Vedyaykin, Galina Cherevatenko, Alexander Yakimov, Dmitry Baitin, Mikhail Khodorkovskii
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-06-01
Series:eLife
Subjects:
RecX
RecA
homologous recombination
DNA repair
SOS response
single-molecule approach
Online Access:https://elifesciences.org/articles/78409

Internet

https://elifesciences.org/articles/78409

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