Estrogen downregulates CD73/adenosine axis hyperactivity via adaptive modulation PI3K/Akt signaling to prevent myocarditis and arrhythmias during chronic catecholamines stress

Estrogen downregulates CD73/adenosine axis hyperactivity via adaptive modulation PI3K/Akt signaling to prevent myocarditis and arrhythmias during chronic catecholamines stress

Abstract Background During myocardial damage, the sex hormone estrogen and CD73, the main enzyme that converts AMP into adenosine, are cardioprotective molecules. However, it is unclear how these two molecules work together to provide cardioprotection. The current study aimed to elucidate the intera...

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Bibliographic Details
Main Authors: Marie Louise Ndzie Noah, Gabriel Komla Adzika, Richard Mprah, Adebayo Oluwafemi Adekunle, Stephane Koda, Joseph Adu-Amankwaah, Yaxin Xu, Kouminin Kanwore, Prosperl Ivette Wowui, Hong Sun
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Cell Communication and Signaling
Subjects:
Catecholamine stress
Cardiac inflammation
CD73
Adenosine
Estrogen
Online Access:https://doi.org/10.1186/s12964-023-01052-0

Internet

https://doi.org/10.1186/s12964-023-01052-0

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