Identifying metabolic adaptations characteristic of cardiotoxicity using paired transcriptomics and metabolomics data integrated with a computational model of heart metabolism.

Identifying metabolic adaptations characteristic of cardiotoxicity using paired transcriptomics and metabolomics data integrated with a computational model of heart metabolism.

Improvements in the diagnosis and treatment of cancer have revealed long-term side effects of chemotherapeutics, particularly cardiotoxicity. Here, we present paired transcriptomics and metabolomics data characterizing in vitro cardiotoxicity to three compounds: 5-fluorouracil, acetaminophen, and do...

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Bibliographic Details
Main Authors: Bonnie V Dougherty, Connor J Moore, Kristopher D Rawls, Matthew L Jenior, Bryan Chun, Sarbajeet Nagdas, Jeffrey J Saucerman, Glynis L Kolling, Anders Wallqvist, Jason A Papin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-02-01
Series:PLoS Computational Biology
Online Access:https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011919&type=printable

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https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1011919&type=printable

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