Impaired immune reconstitution in HIV infection: the role of CD4+ T-cell-associated NKG2D ligands, CD4+ T-cell subsets imbalance, and immune function deficiency

Impaired immune reconstitution in HIV infection: the role of CD4+ T-cell-associated NKG2D ligands, CD4+ T-cell subsets imbalance, and immune function deficiency

ObjectiveThe role of natural killer (NK) cells, which mediate innate immunity, in the immune reconstitution of people living with HIV (PLWH) remains unclear. Our previous research indicated that early activation of CD56dimCD16dim/- NK cells plays an important role in the recovery of CD4+ T cells in...

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Bibliographic Details
Main Authors: Qianqian Xu, Qiuyue Zhang, Peng Xu, Tong Zhang, Hao Wu, Xin Zhang, Christiane Moog, Bin Su
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
immunological non-responders
NK cell ligands
CD4+T cell subsets
HIV
aids
NKG2D
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541574/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2025.1541574/full

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