Characterization of LINE-1 ribonucleoprotein particles.

The average human genome contains a small cohort of active L1 retrotransposons that encode two proteins (ORF1p and ORF2p) required for their mobility (i.e., retrotransposition). Prior studies demonstrated that human ORF1p, L1 RNA, and an ORF2p-encoded reverse transcriptase activity are present in ri...

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Main Authors: Aurélien J Doucet, Amy E Hulme, Elodie Sahinovic, Deanna A Kulpa, John B Moldovan, Huira C Kopera, Jyoti N Athanikar, Manel Hasnaoui, Alain Bucheton, John V Moran, Nicolas Gilbert
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC2951350?pdf=render