Rapid quantitative pharmacodynamic imaging with Bayesian estimation

Rapid quantitative pharmacodynamic imaging with Bayesian estimation

We recently described rapid quantitative pharmacodynamic imaging, a novel method for estimating sensitivity of a biological system to a drug. We tested its accuracy in simulated biological signals with varying receptor sensitivity and varying levels of random noise, and presented initial proof-of-co...

Full description

Bibliographic Details
Main Authors: Jonathan Michael Koller, M. Jonathan Vachon, G. Larry Bretthorst, Kevin J. Black
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-04-01
Series:Frontiers in Neuroscience
Subjects:
fMRI
Drug Development
Pharmacodynamics
cerebral blood flow (CBF)
dose-finding
Bayesian parameter estimation
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00144/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnins.2016.00144/full

Similar Items