L-serine deficiency: on the properties of the Asn133Ser variant of human phosphoserine phosphatase

L-serine deficiency: on the properties of the Asn133Ser variant of human phosphoserine phosphatase

Abstract The non-essential amino acid L-serine is involved in a number of metabolic pathways and in the brain its level is largely due to the biosynthesis from the glycolytic intermediate D-3-phosphoglycerate by the phosphorylated pathway (PP). This cytosolic pathway is made by three enzymes propose...

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Bibliographic Details
Main Authors: Loredano Pollegioni, Barbara Campanini, Jean-Marc Good, Zoraide Motta, Giulia Murtas, Valeria Buoli Comani, Despina-Christina Pavlidou, Noëlle Mercier, Laureane Mittaz-Crettol, Silvia Sacchi, Francesco Marchesani
Format: Article
Language:English
Published: Nature Portfolio 2024-05-01
Series:Scientific Reports
Subjects:
Serine deficiency
Phosphorylated pathway
Genetic disease
Structure–function relationships
Online Access:https://doi.org/10.1038/s41598-024-63164-y

Internet

https://doi.org/10.1038/s41598-024-63164-y

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