Estimating Conditional Power for Sequential Monitoring of Covariate Adaptive Randomized Designs: The Fractional Brownian Motion Approach
Conditional power based on classical Brownian motion (BM) has been widely used in sequential monitoring of clinical trials, including those with the covariate adaptive randomization design (CAR). Due to some uncontrollable factors, the sequential test statistics under CAR procedures may not satisfy...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-09-01
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| Series: | Fractal and Fractional |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2504-3110/5/3/114 |