A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils

A subset of type-II collagen-binding antibodies prevents experimental arthritis by inhibiting FCGR3 signaling in neutrophils

Abstract Rheumatoid arthritis (RA) involves several classes of pathogenic autoantibodies, some of which react with type-II collagen (COL2) in articular cartilage. We previously described a subset of COL2 antibodies targeting the F4 epitope (ERGLKGHRGFT) that could be regulatory. Here, using phage di...

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Bibliographic Details
Main Authors: Zhongwei Xu, Bingze Xu, Susanna L. Lundström, Àlex Moreno-Giró, Danxia Zhao, Myriam Martin, Erik Lönnblom, Qixing Li, Alexander Krämer, Changrong Ge, Lei Cheng, Bibo Liang, Dongmei Tong, Roma Stawikowska, Anna M. Blom, Gregg B. Fields, Roman A. Zubarev, Rikard Holmdahl
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41561-7

Internet

https://doi.org/10.1038/s41467-023-41561-7

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