Heart-specific DNA methylation analysis in plasma for the investigation of myocardial damage

Abstract Background Circulating cell-free DNA (cfDNA) can be released when myocardial damage occurs. Methods Here, we used the methylated CpG tandem amplification and sequencing (MCTA-seq) method for analyzing dynamic changes in heart-derived DNA in plasma samples from myocardial infarction (MI) pat...

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Bibliographic Details
Main Authors: Jie Ren, Lin Jiang, Xiaomeng Liu, Yuhan Liao, Xueyan Zhao, Fuchou Tang, Huimin Yu, Yibing Shao, Jizheng Wang, Lu Wen, Lei Song
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Translational Medicine
Subjects:
Online Access:https://doi.org/10.1186/s12967-022-03234-9