Combined Effect of Bortezomib and Menadione Sodium Bisulfite on Proteasomes of Tumor Cells: The Dramatic Decrease of Bortezomib Toxicity in a Preclinical Trial

Combined Effect of Bortezomib and Menadione Sodium Bisulfite on Proteasomes of Tumor Cells: The Dramatic Decrease of Bortezomib Toxicity in a Preclinical Trial

Tumor growth is associated with elevated proteasome expression and activity. This makes proteasomes a promising target for antitumor drugs. Current antitumor drugs such as bortezomib that inhibit proteasome activity have significant side effects. The purpose of the present study was to develop effec...

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Bibliographic Details
Main Authors: Tatiana M. Astakhova, Alexey V. Morozov, Pavel A. Erokhov, Maria I. Mikhailovskaya, Sergey B. Akopov, Natalia I. Chupikova, Ruslan R. Safarov, Natalia P. Sharova
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Cancers
Subjects:
target and drug discovery
proteasome forms
bortezomib
menadione sodium bisulfite
hepatocellular carcinoma
mammary adenocarcinoma
Lewis lung carcinoma
antitumor effect in vivo
acute toxicity
Online Access:http://www.mdpi.com/2072-6694/10/10/351

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http://www.mdpi.com/2072-6694/10/10/351

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