In vivo epidermal migration requires focal adhesion targeting of ACF7

In vivo epidermal migration requires focal adhesion targeting of ACF7

The spectraplakin protein ACF7 binds to actin at focal adhesions and targets microtubule plus ends to focal adhesions, promoting their disassembly. Here the authors reveal that ACF7 is phosphorylated by Src/FAK, and this regulates actin binding and focal adhesion dynamics in vitro and in vivo.

Bibliographic Details
Main Authors: Jiping Yue, Yao Zhang, Wenguang G. Liang, Xuewen Gou, Philbert Lee, Han Liu, Wanqing Lyu, Wei-Jen Tang, Shao-Yu Chen, Feng Yang, Hong Liang, Xiaoyang Wu
Format: Article
Language:English
Published: Nature Portfolio 2016-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11692

Internet

https://doi.org/10.1038/ncomms11692

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