A Mechanistic Site-Of-Action Model: A Tool for Informing Right Target, Right Compound, And Right Dose for Therapeutic Antagonistic Antibody Programs

A Mechanistic Site-Of-Action Model: A Tool for Informing Right Target, Right Compound, And Right Dose for Therapeutic Antagonistic Antibody Programs

Quantitative modeling is increasingly utilized in the drug discovery and development process, from the initial stages of target selection, through clinical studies. The modeling can provide guidance on three major questions–is this the right target, what are the right compound properties, and what i...

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Bibliographic Details
Main Authors: Georgi I. Kapitanov, Jeffrey R. Chabot, Jatin Narula, Mahua Roy, Hendrik Neubert, Joe Palandra, Vahid Farrokhi, Jay S. Johnson, Robert Webster, Hannah M. Jones
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Bioinformatics
Subjects:
site of action
PKPD
QSP
modeling and simulation
LC-MS
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2021.731340/full

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https://www.frontiersin.org/articles/10.3389/fbinf.2021.731340/full

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