A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice.

A natural variant of obestatin, Q90L, inhibits ghrelin's action on food intake and GH secretion and targets NPY and GHRH neurons in mice.

BACKGROUND: Ghrelin and obestatin are two gut-derived peptides originating from the same ghrelin/obestatin prepropeptide gene (GHRL). While ghrelin stimulates growth hormone (GH) secretion and food intake and inhibits γ-aminobutyric-acid synaptic transmission onto GHRH (Growth Hormone Releasing Horm...

Full description

Bibliographic Details
Main Authors: Rim Hassouna, Philippe Zizzari, Odile Viltart, Seung-Kwon Yang, Robert Gardette, Catherine Videau, Emilio Badoer, Jacques Epelbaum, Virginie Tolle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3519497?pdf=render

Internet

http://europepmc.org/articles/PMC3519497?pdf=render

Similar Items