Step-by-step optimisation of the radiosynthesis of the brain HDAC6 radioligand [18F]FSW-100 for clinical applications

Step-by-step optimisation of the radiosynthesis of the brain HDAC6 radioligand [18F]FSW-100 for clinical applications

Abstract Background Histone deacetylase 6 (HDAC6) is an emerging target for the treatment and diagnosis of proteinopathies. [18F]FSW-100 was recently developed as a promising brain-penetrating radioligand for HDAC6 PET imaging and the process validation of [18F]FSW-100 radiosynthesis for clinical us...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy: Tetsuro Tago, Jun Toyohara
Format: Artykuł
Język:English
Wydane: SpringerOpen 2024-06-01
Seria:EJNMMI Radiopharmacy and Chemistry
Hasła przedmiotowe:
PET
Fluorine-18
Automated radiosynthesis
Copper-mediated radiofluorination
Brain
HDAC6
Dostęp online:https://doi.org/10.1186/s41181-024-00277-9

Internet

https://doi.org/10.1186/s41181-024-00277-9

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