2-O-Acyl-3-O-(1-acyloxyalkyl) Prodrugs of 5,6-Isopropylidene-l-Ascorbic Acid and l-Ascorbic Acid: Antioxidant Activity and Ability to Permeate Silicone Membranes

2-O-Acyl-3-O-(1-acyloxyalkyl) Prodrugs of 5,6-Isopropylidene-l-Ascorbic Acid and l-Ascorbic Acid: Antioxidant Activity and Ability to Permeate Silicone Membranes

2-O-Acyl-3-O-(1-acyloxyalkyl) prodrug derivatives, 15, of 5,6-isopropylidene-l-ascorbic acid, VCA, and l-ascorbic acid, VC, have been characterized by measuring (1) their solubilities in water (SAQ) and in 1-octanol (SOCT); (2) the ability of one member of the homologous series, 15a, to diffuse thro...

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Bibliographic Details
Main Authors: Nikki A. Thiele, Jennifer McGowan, Kenneth B. Sloan
Format: Article
Language:English
Published: MDPI AG 2016-07-01
Series:Pharmaceutics
Subjects:
vitamin C
">l-ascorbic acid
prodrugs
topical delivery
solubilities
cellular antioxidant activity
cytotoxicity
soft alkyl
Online Access:http://www.mdpi.com/1999-4923/8/3/22

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http://www.mdpi.com/1999-4923/8/3/22

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