IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder

IL-18 Signaling in the Rat Central Amygdala Is Disrupted in a Comorbid Model of Post-Traumatic Stress and Alcohol Use Disorder

Alcohol use disorder (AUD) and anxiety disorders are frequently comorbid and share dysregulated neuroimmune-related pathways. Here, we used our established rat model of comorbid post-traumatic stress disorder (PTSD)/AUD to characterize the interleukin 18 (IL-18) system in the central amygdala (CeA)....

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Bibliographic Details
Main Authors: Vittoria Borgonetti, Bryan Cruz, Valentina Vozella, Sophia Khom, Michael Q. Steinman, Ryan Bullard, Shannon D’Ambrosio, Christopher S. Oleata, Roman Vlkolinsky, Michal Bajo, Eric P. Zorrilla, Dean Kirson, Marisa Roberto
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Cells
Subjects:
IL-18
post-traumatic stress disorder
alcohol use disorder
CeA
sex differences
GABA
Online Access:https://www.mdpi.com/2073-4409/12/15/1943

Internet

https://www.mdpi.com/2073-4409/12/15/1943

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