Enterovirus A71 VP1 Variation A289T Decreases the Central Nervous System Infectivity via Attenuation of Interactions between VP1 and Vimentin In Vitro and In Vivo

Enterovirus A71 VP1 Variation A289T Decreases the Central Nervous System Infectivity via Attenuation of Interactions between VP1 and Vimentin In Vitro and In Vivo

Vimentin (VIM) is a surface receptor for enterovirus-A71, mediating the initial binding and subsequent increase in EV-A71 infectivity. The caspid protein VP1 variation, A289T, is reportedly closely associated with less severe central nervous system (CNS) infections in humans. However, it is unclear...

Full description

Bibliographic Details
Main Authors: Huimin Zhu, Yujuan Cao, Weitao Su, Shan Huang, Weizhi Lu, Yezhen Zhou, Jing Gao, Wei Zhao, Bao Zhang, Xianbo Wu
Format: Article
Language:English
Published: MDPI AG 2019-05-01
Series:Viruses
Subjects:
enterovirus A71
VP1 variation
vimentin
central nervous system infectivity
Online Access:https://www.mdpi.com/1999-4915/11/5/467

Internet

https://www.mdpi.com/1999-4915/11/5/467

Similar Items