Streptolysin O Deficiency in Streptococcus pyogenes M1T1 covR/S Mutant Strain Attenuates Virulence in In Vitro and In Vivo Infection Models

Streptolysin O Deficiency in Streptococcus pyogenes M1T1 covR/S Mutant Strain Attenuates Virulence in In Vitro and In Vivo Infection Models

ABSTRACT Mutation within the Streptococcus pyogenes (Streptococcus group A; Strep A) covR/S regulatory system has been associated with a hypervirulent phenotype resulting from the upregulation of several virulence factors, including the pore-forming toxin, streptolysin O (SLO). In this study, we uti...

Full description

Bibliographic Details
Main Authors: Emma L. Langshaw, Simone Reynolds, Victoria Ozberk, Jessica Dooley, Ainslie Calcutt, Mehfuz Zaman, Mark J. Walker, Michael R. Batzloff, Mark R. Davies, Michael F. Good, Manisha Pandey
Format: Article
Language:English
Published: American Society for Microbiology 2023-02-01
Series:mBio
Subjects:
covR/S
J8CombiVax
SLO
Streptococcus pyogenes
dendritic cells
gene expression
Online Access:https://journals.asm.org/doi/10.1128/mbio.03488-22

Internet

https://journals.asm.org/doi/10.1128/mbio.03488-22

Similar Items