The B-Cell-Specific Ablation of B4GALT1 Reduces Cancer Formation and Reverses the Changes in Serum IgG Glycans during the Induction of Mouse Hepatocellular Carcinoma

The B-Cell-Specific Ablation of B4GALT1 Reduces Cancer Formation and Reverses the Changes in Serum IgG Glycans during the Induction of Mouse Hepatocellular Carcinoma

Serum immunoglobulin G (IgG) glycosylation, especially galactosylation, has been found to be related to a variety of tumors, including hepatocellular carcinoma (HCC). However, whether IgG glycan changes occur in the early stages of HCC formation remains unclear. We found that the galactosylation lev...

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Bibliographic Details
Main Authors: Jichen Sha, Rongrong Zhang, Jiteng Fan, Yong Gu, Yiqing Pan, Jing Han, Xiaoyan Xu, Shifang Ren, Jianxin Gu
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Cancers
Subjects:
hepatocellular carcinoma
immunoglobulin G
glycan
β1,4-galactosyltransferase 1
mouse
Online Access:https://www.mdpi.com/2072-6694/14/5/1333

Internet

https://www.mdpi.com/2072-6694/14/5/1333

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