Anti-citrullinated histone monoclonal antibody CIT-013, a dual action therapeutic for neutrophil extracellular trap-associated autoimmune diseases

Anti-citrullinated histone monoclonal antibody CIT-013, a dual action therapeutic for neutrophil extracellular trap-associated autoimmune diseases

ABSTRACTNeutrophil extracellular traps (NETs) contribute to the pathophysiology of multiple inflammatory and autoimmune diseases. Targeting the NETosis pathway has demonstrated significant therapeutic potency in various disease models. Here, we describe a first-in-class monoclonal antibody (CIT-013)...

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Bibliographic Details
Main Authors: Maarten van der Linden, Sangeeta Kumari, Daphne Montizaan, Stephanie van Dalen, Annemarie Kip, Martyn Foster, Inge Reinieren-Beeren, Elsa Neubert, Luise Erpenbeck, Kelsy Waaijenberg, Tirza Bruurmijn, Rezie te Poele, Peter van Zandvoort, Paul Vink, Eric Meldrum, Helmuth van Es, Renato G.S. Chirivi
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:mAbs
Subjects:
Citrullinated histones
mechanism of neutrophil extracellular trap inhibition
neutrophil extracellular trap phagocytosis
rheumatoid arthritis
therapeutic monoclonal antibody
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2023.2281763

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2023.2281763

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