Metabolism and Pharmacokinetics of the Anti-Tuberculosis Drug Ethionamide in a Flavin-Containing Monooxygenase Null Mouse

Metabolism and Pharmacokinetics of the Anti-Tuberculosis Drug Ethionamide in a Flavin-Containing Monooxygenase Null Mouse

Multiple drug resistance (MDR) in Mycobacterium tuberculosis (mTB), the causative agent for tuberculosis (TB), has led to increased use of second-line drugs, including ethionamide (ETA). ETA is a prodrug bioactivated by mycobacterial and mammalian flavin-containing monooxygenases (FMOs). FMO2 is the...

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Bibliographic Details
Main Authors: Amy L. Palmer, Virginia L. Leykam, Andrew Larkin, Sharon K. Krueger, Ian R. Phillips, Elizabeth A. Shephard, David E. Williams
Format: Article
Language:English
Published: MDPI AG 2012-10-01
Series:Pharmaceuticals
Subjects:
ethionamide
flavin-containing monooxygenase
Mycobacterium tuberculosis
Online Access:http://www.mdpi.com/1424-8247/5/11/1147

Internet

http://www.mdpi.com/1424-8247/5/11/1147

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