Case Report: Neonatal Diabetes Mellitus Caused by a Novel GLIS3 Mutation in Twins

Case Report: Neonatal Diabetes Mellitus Caused by a Novel GLIS3 Mutation in Twins

BackgroundMutations in GLIS3 cause a rare syndrome characterized by neonatal diabetes mellitus (NDM), congenital hypothyroidism, congenital glaucoma and cystic kidneys. To date, 14 mutations in GLIS3 have been reported, inherited in an autosomal recessive manner. GLIS3 is a key transcription factor...

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Bibliographic Details
Main Authors: Shira London, Elisa De Franco, Ghadir Elias-Assad, Marie Noufi Barhoum, Clari Felszer, Marina Paniakov, Scott A. Weiner, Yardena Tenenbaum-Rakover
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Endocrinology
Subjects:
β-cell development
congenital glaucoma
congenital hypothyroidism
GLIS3 mutation
neonatal diabetes
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.673755/full

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https://www.frontiersin.org/articles/10.3389/fendo.2021.673755/full

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