COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumors with a poor prognosis. Type X collagen α 1 chain (COL10A1), a member of the collagen family, is a gene associated with the progression of a variety of human tumors, but the specific function and molecular mechanism of...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.1049345/full |
| _version_ | 1811211384400117760 |
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| author | Zhihui Wen Zhihui Wen Zhihui Wen Jingbo Sun Junjie Luo Yun Fu Yue Qiu Yanyan Li Yangwei Xu Hongmei Wu Qingling Zhang Qingling Zhang |
| author_facet | Zhihui Wen Zhihui Wen Zhihui Wen Jingbo Sun Junjie Luo Yun Fu Yue Qiu Yanyan Li Yangwei Xu Hongmei Wu Qingling Zhang Qingling Zhang |
| author_sort | Zhihui Wen |
| collection | DOAJ |
| description | Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumors with a poor prognosis. Type X collagen α 1 chain (COL10A1), a member of the collagen family, is a gene associated with the progression of a variety of human tumors, but the specific function and molecular mechanism of COL10A1 in pancreatic cancer remain unclear. Our study found that COL10A1 is highly expressed in pancreatic cancer cells and tissues, and its high expression is related to poor prognosis and some clinicopathological features, such as tumor size and differentiation. Biological functional experiments showed that overexpression of COL10A1 enhanced the proliferation and migration of PDAC cells. Interestingly, discoid protein domain receptor 2 (DDR2), the receptor of COL10A1, is regulated by COL10A1. We found that the COL10A1-DDR2 axis activates the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, which leads to epithelial-mesenchymal transformation (EMT) and accelerates the progression of pancreatic cancer. In summary, COL10A1 regulates PDAC cell proliferation and MEK/ERK signaling pathways by binding to DDR2 to promote migration, invasion and EMT. Our study suggested that COL10A1 might be a critical factor in promoting PDAC progression. More research is needed to confirm COL10A1 as a potential biomarker and therapeutic target for PDAC. |
| first_indexed | 2024-04-12T05:12:11Z |
| format | Article |
| id | doaj.art-f1df335d22314f919f0c01f346df2098 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T05:12:11Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-f1df335d22314f919f0c01f346df20982022-12-22T03:46:44ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-11-011210.3389/fonc.2022.10493451049345COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transductionZhihui Wen0Zhihui Wen1Zhihui Wen2Jingbo Sun3Junjie Luo4Yun Fu5Yue Qiu6Yanyan Li7Yangwei Xu8Hongmei Wu9Qingling Zhang10Qingling Zhang11Department of Pathology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, ChinaInstitute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of General Surgery, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Pathology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Pathology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Pathology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Pathology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Pathology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Pathology, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, ChinaDepartment of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, ChinaPancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignant tumors with a poor prognosis. Type X collagen α 1 chain (COL10A1), a member of the collagen family, is a gene associated with the progression of a variety of human tumors, but the specific function and molecular mechanism of COL10A1 in pancreatic cancer remain unclear. Our study found that COL10A1 is highly expressed in pancreatic cancer cells and tissues, and its high expression is related to poor prognosis and some clinicopathological features, such as tumor size and differentiation. Biological functional experiments showed that overexpression of COL10A1 enhanced the proliferation and migration of PDAC cells. Interestingly, discoid protein domain receptor 2 (DDR2), the receptor of COL10A1, is regulated by COL10A1. We found that the COL10A1-DDR2 axis activates the mitogen-activated protein kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway, which leads to epithelial-mesenchymal transformation (EMT) and accelerates the progression of pancreatic cancer. In summary, COL10A1 regulates PDAC cell proliferation and MEK/ERK signaling pathways by binding to DDR2 to promote migration, invasion and EMT. Our study suggested that COL10A1 might be a critical factor in promoting PDAC progression. More research is needed to confirm COL10A1 as a potential biomarker and therapeutic target for PDAC.https://www.frontiersin.org/articles/10.3389/fonc.2022.1049345/fullCOL10A1DDR2pancreatic cancermetastasisEMT |
| spellingShingle | Zhihui Wen Zhihui Wen Zhihui Wen Jingbo Sun Junjie Luo Yun Fu Yue Qiu Yanyan Li Yangwei Xu Hongmei Wu Qingling Zhang Qingling Zhang COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction Frontiers in Oncology COL10A1 DDR2 pancreatic cancer metastasis EMT |
| title | COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction |
| title_full | COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction |
| title_fullStr | COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction |
| title_full_unstemmed | COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction |
| title_short | COL10A1-DDR2 axis promotes the progression of pancreatic cancer by regulating MEK/ERK signal transduction |
| title_sort | col10a1 ddr2 axis promotes the progression of pancreatic cancer by regulating mek erk signal transduction |
| topic | COL10A1 DDR2 pancreatic cancer metastasis EMT |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.1049345/full |
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