Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp2)–H activation and C(sp3)–H amination

Intramolecular cascade annulation triggered by rhodium(III)-catalyzed sequential C(sp2)–H activation and C(sp3)–H amination

A rhodium(III)-catalyzed intramolecular oxidative annulation of O-substituted N-hydroxyacrylamides for the construction of indolizinones via sequential C(sp2)–H activation and C(sp3)–H amination has been developed. This approach shows excellent functional-group tolerance. The synthesized scaffold fo...

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Bibliographic Details
Main Authors: Liangliang Song, Guilong Tian, Johan Van der Eycken, Erik V. Van der Eycken
Format: Article
Language:English
Published: Beilstein-Institut 2019-02-01
Series:Beilstein Journal of Organic Chemistry
Subjects:
annulation
C–H activation
rhodium
acrylamide
heterocycles
Online Access:https://doi.org/10.3762/bjoc.15.52

Internet

https://doi.org/10.3762/bjoc.15.52

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