STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice

STING Gain-of-Function Disrupts Lymph Node Organogenesis and Innate Lymphoid Cell Development in Mice

Summary: STING gain-of-function causes autoimmunity and immunodeficiency in mice and STING-associated vasculopathy with onset in infancy (SAVI) in humans. Here, we report that STING gain-of-function in mice prevents development of lymph nodes and Peyer’s patches. We show that the absence of secondar...

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Bibliographic Details
Main Authors: Brock G. Bennion, Carys A. Croft, Teresa L. Ai, Wei Qian, Amber M. Menos, Cathrine A. Miner, Marie-Louis Frémond, Jean-Marc Doisne, Prabhakar S. Andhey, Derek J. Platt, Jennifer K. Bando, Erin R. Wang, Hella Luksch, Thierry J. Molina, Elisha D.O. Roberson, Maxim N. Artyomov, Angela Rösen-Wolff, Marco Colonna, Frédéric Rieux-Laucat, James P. Di Santo, Bénédicte Neven, Jonathan J. Miner
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
STING
ILC
lymphoid tissue organogenesis
lymphopoiesis
SAVI
LTi cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720307518

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http://www.sciencedirect.com/science/article/pii/S2211124720307518

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